Aim: To review the pathophysiology of multiple sclerosis and the resultant ocular motility impairment.
Methods: A literature review was undertaken to ascertain potential ocular motility involvement in cases of multiple sclerosis. This involved a Medline and manual search of relevant journals and transactions.
Results: This review provides background information on the pathophysiology of multiple sclerosis, environmental and genetic factors, ocular motility disturbances at the cortical, cerebellar and brainstem level, and mechanisms of remyelination and relevance to recovery.
Conclusions: This is a practical review of common and uncommon ocular motility disturbances that arise from multiple sclerosis. Recovery relates to inflammatory changes and the remyelination process of damaged nerve axons.